How continuous freeze-drying fits
in the paradigm shift from batch
to continuous manufacturing

The paradigm shift from batch to continuous manufacturing

Continuous manufacturing integrates all unit operations into an uninterrupted production train without a start/stop phase at each unit operation. Raw materials are continuously fed into the process, and finished products are continuously removed. Quality assurance during a continuous process enables continuous monitoring and control of critical process parameters, as well as continuous inspection of quality attributes of end products through at-line, online, or in-line measurements in the process stream.

We have created a White Paper describing how continuous aseptic freeze-drying can address the major pain points of  pharmaceutical batch freeze-drying such as: time-consuming, inefficient, energy-consuming, and poorly controlled.

With a special case study from the company simAbs (simabs.com) which designed a continuous manufacturing process that consistently produces high-quality Drug Substance of monoclonal antibodies.

After more than 50 years it is time for a paradigm shift.